Benzodiazepines and Tricyclic Antidepressant Plasma Levels
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چکیده
منابع مشابه
Benzodiazepines and tricyclic antidepressant plasma levels.
Twelve patients acted successfully as subjects to study what effect if any the benzodiazepines nitrazepam, diazepam, oxazepam, and chlordiazepoxide might have on steady-state plasma levels of nortriptyline and amitriptyline. No significant detectable effect was discovered. In view of the known interaction effects of other alternative tranquillizing drugs and hypnotics it seems reasonable to cho...
متن کاملThe tricyclic antidepressant clomipramine increases plasma glucose levels of mice.
Effects of the tricyclic antidepressant clomipramine on plasma glucose levels in mice were studied. Clomipramine at doses ranging 5 - 20 mg/kg elicited significant hyperglycemia in mice. Hyperglycemia elicited by clomipramine was not reduced by pretreatment with the 5-hydroxytryptamine (5-HT) depleter p-chlorophenylalanine. The 5-HT(1/2/5/7)-receptor antagonist methysergide and the 5-HT(2A/2B/2...
متن کاملBenzodiazepines co-ingestion in reducing tricyclic antidepressant toxicity.
AIM Tricyclic antidepressant (TCA) overdose is generally associated with central nervous system (CNS) and cardiovascular toxicity manifested by seizure, electrocardiographic (ECG) abnormalities and arrhythmia. The objective of this study was to determine whether TCA toxicity would be reduced in patient where benzodiazepine (BDZ) was co-ingested with TCA. DESIGN Patients who were diagnosed to ...
متن کاملCatecholamine levels in tricyclic antidepressant self-poisoning.
In a consecutive series of 208 patients with tricyclic antidepressant self poisoni ng, urinary catec holami ne excretion was measured, and the catecholamine level compared with that in ten patients having taken an overdose of other drugs. In both patient groups the electrocardiograph was monitored continuously for a minimum of 48 hours to detect cardiac arrhythmias. Urinary noradrenaline excret...
متن کاملTricyclic antidepressant toxicity.
Tricyclic antidepressants are dibenzazepine derivatives with adrenergic, anticholinergic, and direct cardio-depressant activity. Double-blind clinical studies show TCAD to be efficacious for two-thirds of depressed patients. Cardiac toxicity is significant, especially on diseased myocardium. Serious arrhythmias and intracardiac blocks have been reported on therapeutic doses. Tricyclic antidepre...
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ژورنال
عنوان ژورنال: BMJ
سال: 1973
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5870.18